Segregation, defined in space syntax, means spaces are deeper from all other spaces. More segregated spaces have higher mean depth values.
Segregation
Sources Hillier, B., Penn, A., Hanson, J., Grajewski, T., and Xu, J. (1993), Natural Movement: or. Configuration and Attraction in Urban Pedestrian Movement. Environment Planning B, 20(1) 29-66. pp. 35